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| カタログ番号 | HB426014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human SULT2A1 Polyclonal Antibody (HB426014) is a rabbit polyclonal antibody detecting Sulfotransferase 2A1; ST2A1; 2.8.2.2; Bile salt sulfotransferase; 2.8.2.14; Dehydroepiandrosterone sulfotransferase; DHEA-ST; DHEA-ST8; Hydroxysteroid Sulfotransferase; HST; ST2; SULT2A3; SULT2A1; HST; STD in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant human SULT2A1 (Met1-Glu285). | ||||||||
| ターゲット | Sulfotransferase 2A1; ST2A1; 2.8.2.2; Bile salt sulfotransferase; 2.8.2.14; Dehydroepiandrosterone sulfotransferase; DHEA-ST; DHEA-ST8; Hydroxysteroid Sulfotransferase; HST; ST2; SULT2A3; SULT2A1; HST; STD | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q06520 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Sulfotransferase 2A1 (SULT2A1) is a ~33 kDa protein. Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism, mediating formation of 3-sulfated bile acids. 1. Chang, HJ. et al. (2004) The Journal of biological chemistry 279, 2689-96. PMID: 14573603 2. Lu, LY. et al. (2008) Molecular pharmacology 73, 660-8. PMID: 18042734 3. Cook, IT. et al. (2009) Drug metabolism and disposition: the biological fate of chemicals 37, 2069-78. PMID: 19589875 4. Huang, J. et al. (2010) Xenobiotica; the fate of foreign compounds in biological systems 40, 184-94. PMID: 20102295 5. Gulcan, HO. et al. (2011) Archives of biochemistry and biophysics 507, 232-40. PMID: 21187059 6. Radominska, A. et al. (1990) The Biochemical journal 272, 597-604. PMID: 2268288 7. Abunnaja, MS. et al. (2018) Biochemistry and cell biology = Biochimie et biologie cellulaire 96, 655-662. PMID: 29671343 8. Comer, KA. et al. (1993) The Biochemical journal 289 ( Pt 1), 233-40. PMID: 7678732 9. Glatt, H. et al. (1994) Mutagenesis 9, 553-7. PMID: 7854148 | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-SULT2A1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
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