Anti-Human SUZ12 Polyclonal Antibody (HC259014)

Name: Anti-Human SUZ12 Polyclonal Antibody
Brand: abinScience
SKU: HC259014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HC259014

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human SUZ12 (Lys587-Gly691).

Cible

SUZ12, Polycomb protein SUZ12, Joined to JAZF1 protein, CHET9, KIAA0160, ChET 9 protein, Suppressor of zeste 12 protein homolog, Chromatin precipitated E2F target 9 protein, JJAZ1

Purification

Purified by antigen affinity column.

Numéro d'accès

Q15022

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Polycomb protein SUZ12 is a ~83 kDa protein. Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

1. Cao, R. et al. (2004) Molecular cell 15, 57-67. PMID: 15225548

2. Kirmizis, A. et al. (2004) Genes & development 18, 1592-605. PMID: 15231737

3. Pasini, D. et al. (2004) The EMBO journal 23, 4061-71. PMID: 15385962

4. Bracken, AP. et al. (2006) Genes & development 20, 1123-36. PMID: 16618801

5. Bracken, AP. et al. (2007) Genes & development 21, 525-30. PMID: 17344414

6. Sarma, K. et al. (2008) Molecular and cellular biology 28, 2718-31. PMID: 18285464

7. Imagawa, E. et al. (2017) Human mutation 38, 637-648. PMID: 28229514

8. Chen, S. et al. (2018) Molecular cell 69, 840-852.e5. PMID: 29499137

9. Chen, S. et al. (2020) Molecular cell 77, 1265-1278.e7. PMID: 31959557

10. Cao, R. et al. (2002) Science (New York, N.Y.) 298, 1039-43. PMID: 12351676

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human SUZ12 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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