

| Каталожный номер | HB146014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human NK1R Polyclonal Antibody (HB146014) is a rabbit polyclonal antibody detecting NK1R in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human TACR1 (Gly166-Glu193). | ||||||||
| Цель | TAC1R, Tachykinin receptor 1, NK-1R, NK1R, SPR, TACR1, Substance-P receptor, NK-1 receptor | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Чистота | >95% as determined by SDS-PAGE. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | P25103 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Substance-P receptor (TACR1/NK-1R) is a ~46 kDa protein. Receptor for the tachykinin substance P, also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K. The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K. Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP). 1. Takeda, Y. et al. (1991) Biochemical and biophysical research communications 179, 1232-40. PMID: 1718267 2. Randolph, GP. et al. (2004) The pharmacogenomics journal 4, 394-402. PMID: 15452552 | ||||||||
| Примечание | For research use only. |



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