

| Каталожный номер | HP681014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human TAOK1 Polyclonal Antibody (HP681014) is a rabbit polyclonal antibody detecting TAOK1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Реактивность видов | Human, Mouse, Rat | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human TAOK1 (Met1-Arg283). | ||||||||
| Цель | MARK Kinase, Thousand and one amino acid protein kinase 1, TAOK1, KIAA1361, Prostate-derived sterile 20-like kinase 2, hKFC-B, Prostate-derived STE20-like kinase 2, PSK-2, MARKK, Kinase from chicken homolog B, Serine/threonine-protein kinase TAO1, hTAOK1, PSK2, MAP3K16 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q7L7X3 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Serine/threonine-protein kinase TAO1 (TAOK1) is a ~116 kDa protein. Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. 1. van Woerden, GM. et al. (2021) Human mutation 42, 445-459. PMID: 33565190 | ||||||||
| Примечание | For research use only. |
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