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| カタログ番号 | HS711014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TARBP2 Polyclonal Antibody (HS711014) is a rabbit polyclonal antibody detecting TARBP2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TARBP2 (Thr264-Lys366). | ||||||||
| ターゲット | RISC-loading complex subunit TARBP2, TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein, TARBP2, TRBP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q15633 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RISC-loading complex subunit TARBP2 is a ~39 kDa protein. Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. 1. Chendrimada, TP. et al. (2005) Nature 436, 740-4. PMID: 15973356 2. Haase, AD. et al. (2005) EMBO reports 6, 961-7. PMID: 16142218 3. Gregory, RI. et al. (2005) Cell 123, 631-40. PMID: 16271387 4. Maniataki, E. et al. (2005) Genes & development 19, 2979-90. PMID: 16357216 5. Lee, Y. et al. (2006) The EMBO journal 25, 522-32. PMID: 16424907 6. Kok, KH. et al. (2007) The Journal of biological chemistry 282, 17649-57. PMID: 17452327 7. MacRae, IJ. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 512-7. PMID: 18178619 8. Fukunaga, R. et al. (2012) Cell 151, 533-46. PMID: 23063653 9. Ling, T. et al. (2019) Molecular immunology 109, 116-125. PMID: 30927622 | ||||||||
| 注意事項 | For research use only. |
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