

| Numéro de catalogue | HC482014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human TCOF1 Polyclonal Antibody (HC482014) is a rabbit polyclonal antibody detecting TCOF1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human TCOF1 (Ala2-Arg77). | ||||||||
| Cible | TCOF1, Treacher Collins syndrome protein, Treacle protein | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q13428 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Treacle protein (TCOF1) is a ~152 kDa protein. Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. 1. Hayano, T. et al. (2003) The Journal of biological chemistry 278, 34309-19. PMID: 12777385 2. Werner, A. et al. (2015) Nature 525, 523-7. PMID: 26399832 | ||||||||
| Note | For research use only. |
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