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| カタログ番号 | HX209014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TERF1 Polyclonal Antibody (HX209014) is a rabbit polyclonal antibody detecting TERF1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TERF1 (Arg94-Ser253). | ||||||||
| ターゲット | TRF1, PIN2, Telomeric protein Pin2/TRF1, TERF1, TTAGGG repeat-binding factor 1, TRF, Telomeric repeat-binding factor 1, NIMA-interacting protein 2, TRBF1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P54274 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Telomeric repeat-binding factor 1 (TERF1) is a ~50 kDa protein. Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. 1. Li, P. et al. (2019) International journal of biological sciences 15, 2350-2362. PMID: 31595153 | ||||||||
| 注意事項 | For research use only. |
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