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| カタログ番号 | HX990014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TFAM Polyclonal Antibody (HX990014) is a rabbit polyclonal antibody detecting TFAM in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TFAM (Ser43-Cys246). | ||||||||
| ターゲット | Transcription factor 6-like 2, Mitochondrial transcription factor 1, MtTF1, mtTFA, Transcription factor 6, TCF6, TCF6L2, Transcription factor A, mitochondrial, TCF-6, TFAM | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q00059 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transcription factor A, mitochondrial (TFAM) is a ~29 kDa protein. Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. 1. Celestini, V. et al. (2018) Cell death & disease 9, 231. PMID: 29445193 2. Hao, Z. et al. (2020) Molecular cell 78, 382-395.e8. PMID: 32183942 3. Hillen, HS. et al. (2017) Cell 171, 1072-1081.e10. PMID: 29149603 4. Litonin, D. et al. (2010) The Journal of biological chemistry 285, 18129-33. PMID: 20410300 5. Rubio-Cosials, A. et al. (2011) Nature structural & molecular biology 18, 1281-9. PMID: 22037172 6. Fisher, RP. et al. (1992) The Journal of biological chemistry 267, 3358-67. PMID: 1737790 7. Gangelhoff, TA. et al. (2009) Nucleic acids research 37, 3153-64. PMID: 19304746 8. Kasashima, K. et al. (2012) Experimental cell research 318, 2335-43. PMID: 22841477 | ||||||||
| 注意事項 | For research use only. |
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