Anti-Human TFAM Polyclonal Antibody (HX990014)

Name: Anti-Human TFAM Polyclonal Antibody
Brand: abinScience
SKU: HX990014
Price: 168 USD
Availability: InStock

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Каталожный номер

HX990014

Описание

Anti-Human TFAM Polyclonal Antibody (HX990014) is a rabbit polyclonal antibody detecting TFAM in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human TFAM (Ser43-Cys246).

Цель

Transcription factor 6-like 2, Mitochondrial transcription factor 1, MtTF1, mtTFA, Transcription factor 6, TCF6, TCF6L2, Transcription factor A, mitochondrial, TCF-6, TFAM

Очистка

Purified by antigen affinity column.

Номер доступа

Q00059

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Transcription factor A, mitochondrial (TFAM) is a ~29 kDa protein. Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites.

1. Celestini, V. et al. (2018) Cell death & disease 9, 231. PMID: 29445193

2. Hao, Z. et al. (2020) Molecular cell 78, 382-395.e8. PMID: 32183942

3. Hillen, HS. et al. (2017) Cell 171, 1072-1081.e10. PMID: 29149603

4. Litonin, D. et al. (2010) The Journal of biological chemistry 285, 18129-33. PMID: 20410300

5. Rubio-Cosials, A. et al. (2011) Nature structural & molecular biology 18, 1281-9. PMID: 22037172

6. Fisher, RP. et al. (1992) The Journal of biological chemistry 267, 3358-67. PMID: 1737790

7. Gangelhoff, TA. et al. (2009) Nucleic acids research 37, 3153-64. PMID: 19304746

8. Kasashima, K. et al. (2012) Experimental cell research 318, 2335-43. PMID: 22841477

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human TFAM Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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Anti-Human TFAM Polyclonal Antibody (HX990014)

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