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| カタログ番号 | HB043014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TFE3 (Asn185-Ser281). | ||||||||
| ターゲット | TFE3, bHLHe33, BHLHE33, Transcription factor E3, Class E basic helix-loop-helix protein 33 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P19532 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transcription factor E3 (TFE3) is a ~61 kDa protein. Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response. Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes. 1. Beckmann, H. et al. (1990) Genes & development 4, 167-79. PMID: 2338243 2. Martina, JA. et al. (2014) Science signaling 7, ra9. PMID: 24448649 3. Willett, R. et al. (2017) Nature communications 8, 1580. PMID: 29146937 4. Mathieu, J. et al. (2019) Nature communications 10, 632. PMID: 30733432 5. Lawrence, RE. et al. (2019) Science (New York, N.Y.) 366, 971-977. PMID: 31672913 6. Malik, N. et al. (2023) Science (New York, N.Y.) 380, eabj5559. PMID: 37079666 7. Nardone, C. et al. (2023) Molecular cell 83, 57-73.e9. PMID: 36608670 | ||||||||
| 注意事項 | For research use only. |
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