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| カタログ番号 | HB247013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, FuncS | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgA, kappa | ||||
| クローンID | SAA2703 | ||||
| ターゲット | EC:2.3.1.-, EC:2.3.2.13, EC:3.4.-.-, EC:3.5.1.44, Erythrocyte transglutaminase, G(h), Heart G alpha(h), Isopeptidase TGM2, Protein G alpha(h), Protein-glutamine deamidase TGM2, Protein-glutamine dopaminyltransferase TGM2, Protein-glutamine gamma-glutamyltransferase 2, Protein-glutamine histaminyltransferase TGM2, Protein-glutamine noradrenalinyltransferase TGM2, Protein-glutamine serotonyltransferase TGM2, TG(C), TG2, TGC, TGM2, TGase C, TGase H, TGase II, TGase-2, Tissue transglutaminase, Transglutaminase C, Transglutaminase H, Transglutaminase II, Transglutaminase-2, hTG2, hhG alpha(h), tTG, tTgase | ||||
| エンドトキシンレベル | < 10 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P21980 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a ~77 kDa protein. Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively. Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis. Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54. Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses. When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds. 1. Kanchan, K. et al. (2013) The Biochemical journal 455, 261-72. PMID: 23941696 2. Jeong, EM. et al. (2020) International journal of molecular sciences 21. PMID: 31991788 3. Nemes, Z. et al. (1997) The Journal of biological chemistry 272, 20577-83. PMID: 9252372 4. Upchurch, HF. et al. (1991) Journal of cellular physiology 149, 375-82. PMID: 1683874 5. Lai, TS. et al. (2017) Amino acids 49, 501-515. PMID: 27270573 6. Hernandez-Fernaud, JR. et al. (2017) Nature communications 8, 14206. PMID: 28198360 7. Melino, G. et al. (1994) Molecular and cellular biology 14, 6584-96. PMID: 7935379 8. Hsieh, YF. et al. (2013) PloS one 8, e81516. PMID: 24349085 | ||||
| 注意事項 | For research use only |
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