Anti-Human THOC5 Polyclonal Antibody (HD208014)

Name: Anti-Human THOC5 Polyclonal Antibody
Brand: abinScience
SKU: HD208014
Price: 168 USD
Availability: InStock

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Каталожный номер

HD208014

Описание

Anti-Human THOC5 Polyclonal Antibody (HD208014) is a rabbit polyclonal antibody detecting THOC5. Suitable for Rat, Mouse, and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse, Rat

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human THOC5 (His263-Arg683).

Цель

C22orf19, Functional spliceosome-associated protein 79, KIAA0983, NF2/meningioma region protein pK1.3, PP39.2, Placental protein 39.2, THO complex subunit 5, THOC5, fSAP79, hTREX90

Уровень эндотоксинов

Please contact with the lab for this information.

Очистка

Purified by antigen affinity column.

Номер доступа

Q13769

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Фон

THO complex subunit 5 (THOC5) is a ~78 kDa protein. Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability.

1. Guo, S. et al. (2005) Cancer research 65, 3011-6. PMID: 15833825

2. Masuda, S. et al. (2005) Genes & development 19, 1512-7. PMID: 15998806

3. Cheng, H. et al. (2006) Cell 127, 1389-400. PMID: 17190602

4. Pühringer, T. et al. (2020) eLife 9. PMID: 33191911

5. Boyne, JR. et al. (2008) PLoS pathogens 4, e1000194. PMID: 18974867

6. Katahira, J. et al. (2013) Nucleic acids research 41, 7060-72. PMID: 23685434

Примечание

For research use only

Изображения

Ссылки

Даташит

Anti-Human THOC5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

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Anti-Human THOC5 Polyclonal Antibody (HD208014)

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