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| カタログ番号 | HA527014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human THOC7 Polyclonal Antibody (HA527014) is a rabbit polyclonal antibody detecting THOC7 in ELISA, IHC, WB. Suitable for Xenopus tropicalis, Xenopus laevis, Bovine, and Mus musculus.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human THOC7 (Met1-Pro204). | ||||||||
| ターゲット | THOC7 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q6I9Y2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | THO complex subunit 7 homolog, Functional spliceosome-associated protein 24, fSAP24, Ngg1-interacting factor 3-like protein 1-binding protein 1, NIF3L1-binding protein 1, hTREX30, THOC7, NIF3L1BP1 | ||||||||
| 背景 | THO complex subunit 7 (THOC7) is a ~23 kDa protein. Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. 1. Guo, S. et al. (2005) Cancer research 65, 3011-6. PMID: 15833825 2. Masuda, S. et al. (2005) Genes & development 19, 1512-7. PMID: 15998806 3. Cheng, H. et al. (2006) Cell 127, 1389-400. PMID: 17190602 4. Chi, B. et al. (2013) Nucleic acids research 41, 1294-306. PMID: 23222130 5. Pühringer, T. et al. (2020) eLife 9. PMID: 33191911 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-THOC7 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse skin lysate
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