Anti-Human THOC7 Polyclonal Antibody (HA527014)

Name: Anti-Human THOC7 Polyclonal Antibody
Brand: abinScience
SKU: HA527014
Price: 96 USD
Availability: InStock

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Обзор

Каталожный номер

HA527014

Описание

Anti-Human THOC7 Polyclonal Antibody (HA527014) is a rabbit polyclonal antibody detecting THOC7 in ELISA, IHC, WB. Suitable for Xenopus tropicalis, Xenopus laevis, Bovine, and Mus musculus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human THOC7 (Met1-Pro204).

Цель

THOC7

Очистка

Purified by antigen affinity column.

Номер доступа

Q6I9Y2

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Альтернативные названия

THO complex subunit 7 homolog, Functional spliceosome-associated protein 24, fSAP24, Ngg1-interacting factor 3-like protein 1-binding protein 1, NIF3L1-binding protein 1, hTREX30, THOC7, NIF3L1BP1

Фон

THO complex subunit 7 (THOC7) is a ~23 kDa protein. Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway.

1. Guo, S. et al. (2005) Cancer research 65, 3011-6. PMID: 15833825

2. Masuda, S. et al. (2005) Genes & development 19, 1512-7. PMID: 15998806

3. Cheng, H. et al. (2006) Cell 127, 1389-400. PMID: 17190602

4. Chi, B. et al. (2013) Nucleic acids research 41, 1294-306. PMID: 23222130

5. Pühringer, T. et al. (2020) eLife 9. PMID: 33191911

Примечание

For research use only.

Изображения

Western blot

Western blot analysis was performed using anti-THOC7 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse skin lysate

Ссылки

Даташит

Anti-Human THOC7 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

Concentration

Volume

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g/mol

Formula

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C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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