Anti-Human TIF1/TRIM24 IP Recombinant Antibody (SAA0265) (HT332013)

Name: Anti-Human TIF1/TRIM24 IP Recombinant Antibody (SAA0265)
Brand: abinScience
SKU: HT332013
Price: 191 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HT332013

Reactividad de especies

Human

Aplicaciones

ELISA, IF, IP

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a

ID de clon

SAA0265

Objetivo

RING-type E3 ubiquitin transferase TIF1-alpha, TIF1-alpha, RING finger protein 82, Transcription intermediary factor 1-alpha, RNF82, Tripartite motif-containing protein 24, E3 ubiquitin-protein ligase TRIM24, TIF1, TIF1A, TRIM24

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

O15164

RRID

Anti-Human TIF1/TRIM24 IP Antibody (SAA0265) (abinScience Cat# HT332013, RRID:AB_3729799)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Transcription intermediary factor 1-alpha (TIF1/TRIM24) is a ~116 kDa protein. Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation.

1. Jain, AK. et al. (2014) Molecular and cellular biology 34, 2695-709. PMID: 24820418

2. Zhu, Q. et al. (2020) The Journal of experimental medicine 217. PMID: 32324863

3. Hang, Y. et al. (2021) Cell biology international 45, 1561-1570. PMID: 33724611

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human TIF1/TRIM24 IP Antibody (SAA0265)

Referencias

Datasheet

Anti-Human TIF1/TRIM24 IP Recombinant Antibody (SAA0265).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo