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| カタログ番号 | HT332013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | SAA0265 | ||||
| ターゲット | RING-type E3 ubiquitin transferase TIF1-alpha, TIF1-alpha, RING finger protein 82, Transcription intermediary factor 1-alpha, RNF82, Tripartite motif-containing protein 24, E3 ubiquitin-protein ligase TRIM24, TIF1, TIF1A, TRIM24 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O15164 | ||||
| RRID | Anti-Human TIF1/TRIM24 IP Antibody (SAA0265) (abinScience Cat# HT332013, RRID:AB_3729799) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Transcription intermediary factor 1-alpha (TIF1/TRIM24) is a ~116 kDa protein. Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. 1. Jain, AK. et al. (2014) Molecular and cellular biology 34, 2695-709. PMID: 24820418 2. Zhu, Q. et al. (2020) The Journal of experimental medicine 217. PMID: 32324863 3. Hang, Y. et al. (2021) Cell biology international 45, 1561-1570. PMID: 33724611 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human TIF1/TRIM24 IP Antibody (SAA0265)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
