

| Numéro de catalogue | HT023014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human TM4SF5 Polyclonal Antibody (HT023014) is a rabbit polyclonal antibody detecting TM4SF5 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human TM4SF5 (Leu112-Thr157). | ||||||||
| Cible | Transmembrane 4 L6 family member 5, Tetraspan transmembrane protein L6H, TM4SF5 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | O14894 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
||||||||
| Informations d'utilisation du produit |
| ||||||||
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Transmembrane 4 L6 family member 5 (TM4SF5) is a ~20 kDa protein. Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression. 1. Jung, JW. et al. (2019) Cell metabolism 29, 1306-1319.e7. PMID: 30956113 2. Kim, H. et al. (2010) Biochimica et biophysica acta 1803, 975-82. PMID: 20399237 | ||||||||
| Note | For research use only. |
Contactez-nous pour les devis personnalisés, les demandes en gros et tout autre problème.
Courrier : [email protected]
Accès rapide
Contactez-nous
+86-027-65523339
Bâtiment C, No. 666, Rue Shendunsi, Wuhan, 430206, Chine
中文
English
한국어
日本語
Español
Français
Русский