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| カタログ番号 | HW693014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TMED10 Polyclonal Antibody (HW693014) is a rabbit polyclonal antibody detecting TMED10 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TMED10 (Ile32-Lys133). | ||||||||
| ターゲット | S31I125, Tmp-21-I, Transmembrane protein Tmp21, Transmembrane emp24 domain-containing protein 10, TMP21, TMED10, 21 kDa transmembrane-trafficking protein, p23, S31III125, Protein TMED10, p24delta1, p24 family protein delta-1, p24delta | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P49755 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transmembrane emp24 domain-containing protein 10 (TMED10) is a ~24 kDa protein. Cargo receptor involved in protein vesicular trafficking and quality control in the endoplasmic reticulum (ER) and Golgi. The p24 protein family is a group of transmembrane proteins that bind coat protein complex I/COPI and coat protein complex II/COPII involved in vesicular trafficking between the membranes. Acts at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and involved in vesicle coat formation at the cytoplasmic side. Mainly functions in the early secretory pathway and cycles between the ER, ER-Golgi intermediate compartment (ERGIC) and Golgi, mediating cargo transport through COPI and COPII-coated vesicles. In COPII vesicle-mediated anterograde transport, involved in the transport of GPI-anchored proteins by acting together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. 1. Bremser, M. et al. (1999) Cell 96, 495-506. PMID: 10052452 2. Gommel, DU. et al. (2001) The EMBO journal 20, 6751-60. PMID: 11726511 3. Chen, F. et al. (2006) Nature 440, 1208-12. PMID: 16641999 4. Vetrivel, KS. et al. (2007) Molecular neurodegeneration 2, 4. PMID: 17288597 5. Luo, R. et al. (2009) Cellular signalling 21, 1169-79. PMID: 19296914 6. Bonnon, C. et al. (2010) Journal of cell science 123, 1705-15. PMID: 20427317 7. Luo, W. et al. (2011) Journal of neurochemistry 117, 71-81. PMID: 21219331 8. Nagae, M. et al. (2016) Journal of molecular biology 428, 4087-4099. PMID: 27569046 | ||||||||
| 注意事項 | For research use only. |
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