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Anti-Human TMEFF1 Recombinant Antibody (30C10), APC (HP664137)

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Aperçu
Numéro de catalogueHP664137
Reactivité des espècesHuman
ApplicationsELISA, FCM
Espèce hôteMouse
ClonalitéMonoclonal
IsotypeIgG2a, kappa
ID de clone30C10
ConjugaisonAPC
Cible C9orf2, H7365, TMEFF1, TR-1, Transmembrane protein with EGF-like and one follistatin-like domain, Tomoregulin-1
Niveau d'endotoxines Please contact with the lab for this information.
Produits associés Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC
Numéro d'accès Q8IYR6
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Stabilité et stockage Store at 4°C for 12 months. Protect from light. Do not freeze.
Contexte

Tomoregulin-1 (TMEFF1) is a ~40 kDa protein. Neuron-specific restriction factor that prevents herpes simplex virus 1 (HHV-1) infection in the brain by blocking viral entry. Also able to restrict herpes simplex virus 2 (HHV-2) infection, although to a lesser extent. Acts by preventing the association between the viral glycoprotein D (gD) and its cell surface receptor NECTIN1, thereby inhibiting fusion of the virus and the cell membrane. Also able to prevent the association between the viral glycoprotein B (gB) and MYH9/NMMHC-IIA and MYH10/NMMHC-IIB receptors. May be a tumor suppressor in brain cancers.

1. Dai, Y. et al. (2024) Nature 632, 383-389. PMID: 39048823
2. Chan, YH. et al. (2024) Nature 632, 390-400. PMID: 39048830
3. Gery, S. et al. (2003) Oncogene 22, 2723-7. PMID: 12743596
Note For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.
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Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₂ (Working Conc.)
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