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| カタログ番号 | HP219014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TMEM165 Polyclonal Antibody (HP219014) is a rabbit polyclonal antibody detecting TMEM165 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TMEM165 (Gly34-Thr89). | ||||||||
| ターゲット | TPARL, TMEM165, Transmembrane protein PT27, Transmembrane protein TPARL, Transmembrane protein 165 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9HC07 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Putative divalent cation/proton antiporter TMEM165 is a ~34 kDa protein. Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway. Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk. The transport mechanism and stoichiometry remains to be elucidated. 1. Foulquier, F. et al. (2012) American journal of human genetics 91, 15-26. PMID: 22683087 2. Demaegd, D. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 6859-64. PMID: 23569283 3. Potelle, S. et al. (2016) Human molecular genetics 25, 1489-500. PMID: 27008884 4. Stribny, J. et al. (2020) The Journal of biological chemistry 295, 3865-3874. PMID: 32047108 | ||||||||
| 注意事項 | For research use only. |
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