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| カタログ番号 | HT176023 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, Inhibition | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | VHH-Fc | ||||
| クローンID | SAA2325 | ||||
| ターゲット | Transmembrane protease serine 2, EC:3.4.21.122, Serine protease 10, Transmembrane protease serine 2 non-catalytic chain, Transmembrane protease serine 2 catalytic chain, TMPRSS2, PRSS10 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O15393 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Transmembrane protease serine 2 (TMPRSS2) is a ~53 kDa protein. Plasma membrane-anchored serine protease that cleaves at arginine residues. Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia. 1. Bestle, D. et al. (2020) Life science alliance 3. PMID: 32703818 2. Fraser, BJ. et al. (2022) Nature chemical biology 18, 963-971. PMID: 35676539 3. Wang, H. et al. (2023) Nature communications 14, 7574. PMID: 37990007 4. McCallum, M. et al. (2024) Cell 187, 4231-4245.e13. PMID: 38964328 5. Lucas, JM. et al. (2014) Cancer discovery 4, 1310-25. PMID: 25122198 6. Wilson, S. et al. (2005) The Biochemical journal 388, 967-72. PMID: 15537383 7. Ko, CJ. et al. (2015) Cancer research 75, 2949-60. PMID: 26018085 | ||||
| 注意事項 | For research use only |
SDS-PAGE for Anti-Human TMPRSS2 Antibody (SAA2325)
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
