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  • 1mg
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Обзор
Каталожный номерHT176013
Описание
Anti-Human TMPRSS2 Nanobody (SAA2324) [SAA2324] (HT176013) is a human monoclonal antibody detecting TMPRSS2 in ELISA, Inhibition. Suitable for Human.
Реактивность видовAlpaca
ПримененияELISA, Inhibition
Хозяинский видHuman
КлоональностьMonoclonal
ИзотипVHH-His
ID клонаSAA2324
Цель Transmembrane protease serine 2, EC:3.4.21.122, Serine protease 10, Transmembrane protease serine 2 non-catalytic chain, Transmembrane protease serine 2 catalytic chain, TMPRSS2, PRSS10
Уровень эндотоксинов Please contact with the lab for this information.
Чистота >95% as determined by SDS-PAGE.
Очистка Purified by Nickel column
Номер доступа O15393
Форма Liquid
Буфер хранения 0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Реконституция Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Информация об использовании продукта
Применение Разбавление
ELISA 1:2000-1:20000
Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон

Transmembrane protease serine 2 (TMPRSS2) is a ~53 kDa protein. Plasma membrane-anchored serine protease that cleaves at arginine residues. Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.

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1. Bestle, D. et al. (2020) Life science alliance 3. PMID: 32703818
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2. Fraser, BJ. et al. (2022) Nature chemical biology 18, 963-971. PMID: 35676539
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3. Wang, H. et al. (2023) Nature communications 14, 7574. PMID: 37990007
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4. McCallum, M. et al. (2024) Cell 187, 4231-4245.e13. PMID: 38964328
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5. Lucas, JM. et al. (2014) Cancer discovery 4, 1310-25. PMID: 25122198
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6. Wilson, S. et al. (2005) The Biochemical journal 388, 967-72. PMID: 15537383
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7. Ko, CJ. et al. (2015) Cancer research 75, 2949-60. PMID: 26018085
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Примечание For research use only
Изображения
Ссылки
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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