Anti-Human TMPRSS2 Polyclonal Antibody (HT176024)

Name: Anti-Human TMPRSS2 Polyclonal Antibody
Brand: abinScience
SKU: HT176024
Price: 168 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HT176024

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human TMPRSS2 (Met109-Gly492).

Objetivo

Transmembrane protease serine 2, 3.4.21.122, Serine protease 10, Transmembrane protease serine 2 non-catalytic chain, Transmembrane protease serine 2 catalytic chain, TMPRSS2, PRSS10

Purificación

Purified by antigen affinity column.

Número de acceso

O15393

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Transmembrane protease serine 2 (TMPRSS2) is a ~53 kDa protein. Plasma membrane-anchored serine protease that cleaves at arginine residues. Participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.

1. Bestle, D. et al. (2020) Life science alliance 3. PMID: 32703818

2. Fraser, BJ. et al. (2022) Nature chemical biology 18, 963-971. PMID: 35676539

3. Wang, H. et al. (2023) Nature communications 14, 7574. PMID: 37990007

4. McCallum, M. et al. (2024) Cell 187, 4231-4245.e13. PMID: 38964328

5. Lucas, JM. et al. (2014) Cancer discovery 4, 1310-25. PMID: 25122198

6. Wilson, S. et al. (2005) The Biochemical journal 388, 967-72. PMID: 15537383

7. Ko, CJ. et al. (2015) Cancer research 75, 2949-60. PMID: 26018085

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human TMPRSS2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo