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Anti-Human TNFAIP8L2 Polyclonal Antibody (HP334014)

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Número de catálogoHP334014
Descripción
Anti-Human TNFAIP8L2 Polyclonal Antibody (HP334014) is a rabbit polyclonal antibody detecting TNFAIP8L2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Callithrix jacchus.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human TNFAIP8L2 (Met1-Leu184).
Objetivo TNF alpha-induced protein 8-like protein 2, Tumor necrosis factor alpha-induced protein 8-like protein 2, TNFAIP8-like protein 2, Inflammation factor protein 20, TIPE2, TNFAIP8L2
Purificación Purified by antigen affinity column.
Número de acceso Q6P589
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) is a ~20 kDa protein. Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression. Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness. Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex. Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity.

1. Suo, LG. et al. (2016) Molecular immunology 73, 46-52. PMID: 27043859
2. Lou, Y. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 2122-2132. PMID: 32188758
3. Li, W. et al. (2021) Autophagy 17, 1410-1425. PMID: 32460619
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human TNFAIP8L2 Polyclonal Antibody

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