

| Número de catálogo | HV676014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactividad de especies | Human | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human TNIP2 (Leu31-Glu184). | ||||||||
| Objetivo | A20-binding inhibitor of NF-kappa-B activation 2, ABIN2, ABIN-2, FLIP1, TNFAIP3-interacting protein 2, TNIP2, Fetal liver LKB1-interacting protein | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q8NFZ5 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | TNFAIP3-interacting protein 2 (TNIP2) is a ~48 kDa protein. Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. | ||||||||
| Nota | For research use only. |
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