

| Каталожный номер | HV676014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human TNIP2 (Leu31-Glu184). | ||||||||
| Цель | A20-binding inhibitor of NF-kappa-B activation 2, ABIN2, ABIN-2, FLIP1, TNFAIP3-interacting protein 2, TNIP2, Fetal liver LKB1-interacting protein | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q8NFZ5 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | TNFAIP3-interacting protein 2 (TNIP2) is a ~48 kDa protein. Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. | ||||||||
| Примечание | For research use only. |
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