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| カタログ番号 | HP793014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TOMM22 Polyclonal Antibody (HP793014) is a rabbit polyclonal antibody detecting TOMM22 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TOMM22 (Glu42-Ala84). | ||||||||
| ターゲット | 1C9-2, TOM22, Translocase of outer membrane 22 kDa subunit homolog, hTom22, Mitochondrial import receptor subunit TOM22 homolog, TOMM22 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9NS69 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) is a ~15 kDa protein. Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases. 1. Callegari, S. et al. (2025) Science (New York, N.Y.) 388, 303-310. PMID: 40080546 2. Yano, M. et al. (2000) Molecular and cellular biology 20, 7205-13. PMID: 10982837 | ||||||||
| 注意事項 | For research use only. |
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