Anti-Human p53 Recombinant Antibody (163.6#) (HY039053)

Name: Anti-Human p53 Recombinant Antibody (163.6#)
Brand: abinScience
SKU: HY039053
Price: 196 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HY039053

Reactividad de especies

Human

Aplicaciones

ELISA, WB

Especie huésped

Mouse

Clonalidad

Monoclonal

Isotipo

IgG2a, kappa

ID de clon

163.6#

Objetivo

TP53, Cellular tumor antigen p53, Tumor suppressor p53

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

P04637

RRID

Anti-Human TP53/p53 Antibody (163.6#) (abinScience Cat# HY039053, RRID:AB_3727129)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Fondo

Cellular tumor antigen p53 (TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

1. Guo, A. et al. (2000) Nature cell biology 2, 730-6. PMID: 11025664

2. Bergamaschi, D. et al. (2003) Nature genetics 33, 162-7. PMID: 12524540

3. Louria-Hayon, I. et al. (2003) The Journal of biological chemistry 278, 33134-41. PMID: 12810724

4. An, W. et al. (2004) Cell 117, 735-48. PMID: 15186775

5. Ghosh, A. et al. (2004) Molecular and cellular biology 24, 7987-97. PMID: 15340061

6. Zhao, Y. et al. (2007) The Journal of biological chemistry 282, 11969-81. PMID: 17317671

7. Taira, N. et al. (2007) Molecular cell 25, 725-38. PMID: 17349958

8. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538

9. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990

10. Wu, L. et al. (2011) The Journal of biological chemistry 286, 2236-44. PMID: 20959462

Nota

For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Anti-Human TP53/p53 Antibody (163.6#)

Referencias

Datasheet

Anti-Human p53 Recombinant Antibody (163.6#).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo