Anti-Human p53 Polyclonal Antibody (HY039034)

Name: Anti-Human p53 Polyclonal Antibody
Brand: abinScience
SKU: HY039034
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HY039034

Descripción

Anti-Human TP53 Polyclonal Antibody (HY039034) is a rabbit polyclonal antibody detecting Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53; P53. Suitable for Human.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human TP53 (Glu2-Asp393).

Aplicaciones probadas

Objetivo

Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53; P53

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P04637

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Fondo

Cellular tumor antigen p53 (TP53) is a ~43 kDa protein. Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

1. Guo, A. et al. (2000) Nature cell biology 2, 730-6. PMID: 11025664

2. Bergamaschi, D. et al. (2003) Nature genetics 33, 162-7. PMID: 12524540

3. Louria-Hayon, I. et al. (2003) The Journal of biological chemistry 278, 33134-41. PMID: 12810724

4. An, W. et al. (2004) Cell 117, 735-48. PMID: 15186775

5. Ghosh, A. et al. (2004) Molecular and cellular biology 24, 7987-97. PMID: 15340061

6. Zhao, Y. et al. (2007) The Journal of biological chemistry 282, 11969-81. PMID: 17317671

7. Taira, N. et al. (2007) Molecular cell 25, 725-38. PMID: 17349958

8. Allton, K. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 11612-6. PMID: 19556538

9. Huarte, M. et al. (2010) Cell 142, 409-19. PMID: 20673990

10. Wu, L. et al. (2011) The Journal of biological chemistry 286, 2236-44. PMID: 20959462

Nota

For research use only

Imágenes

Western blot

Lane 1: A431 cell lysate
Lane 2: HT-29 cell lysate
Lane 3: Hacat cell lysate

Referencias

Datasheet

Anti-Human p53 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

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