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| カタログ番号 | HP992014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TRAIP Polyclonal Antibody (HP992014) is a rabbit polyclonal antibody detecting TRAIP in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRAIP (Pro2-Asp75). | ||||||||
| ターゲット | TRIP, RING finger protein 206, RNF206, TRAF-interacting protein, E3 ubiquitin-protein ligase TRAIP, TRAIP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9BWF2 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase TRAIP is a ~53 kDa protein. E3 ubiquitin ligase required to protect genome stability in response to replication stress. Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription. Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex. Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3. If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway. 1. Chapard, C. et al. (2014) Journal of cell science 127, 5149-56. PMID: 25335891 2. Harley, ME. et al. (2016) Nature genetics 48, 36-43. PMID: 26595769 3. Hoffmann, S. et al. (2016) The Journal of cell biology 212, 63-75. PMID: 26711499 4. Soo Lee, N. et al. (2016) Nature communications 7, 10463. PMID: 26781088 5. Feng, W. et al. (2016) Cell discovery 2, 16016. PMID: 27462463 6. Sonneville, R. et al. (2019) eLife 8. PMID: 31545170 7. Wallace, HA. et al. (2014) Development (Cambridge, England) 141, 1332-41. PMID: 24553286 8. Zhang, M. et al. (2012) The Journal of experimental medicine 209, 1703-11. PMID: 22945920 | ||||||||
| 注意事項 | For research use only. |
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