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Anti-Human TRBC2 Recombinant Antibody (SAA1764) (HP477013)

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Anti-Human TRBC2 Recombinant Antibody (SAA1764)
Anti-Human TRBC2 Recombinant Antibody (SAA1764)
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Aperçu
Numéro de catalogueHP477013
Description
Anti-Human TRBC2 Recombinant Antibody (SAA1764) (HP477013) is a mouse monoclonal antibody detecting TRBC2 in ELISA. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
Reactivité des espècesHuman
ApplicationsELISA
Espèce hôteMouse
ClonalitéMonoclonal
IsotypeIgG2a, kappa
ID de cloneSAA1764
Cible TRBC2, TCRBC2, T cell receptor beta constant 2
Niveau d'endotoxines < 10 EU/mg as determined by LAL method.
Pureté >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Numéro d'accès A0A5B9
RRID Anti-Human TRBC2 Antibody (SAA1764) (abinScience Cat# HP477013, RRID:AB_3727525)
Forme Liquid
Tampon de stockage 0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:2000-1:20000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Contexte

T cell receptor beta constant 2 (TRBC2) is a ~19 kDa protein. Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.

1. Lefranc, MP. (2014) Frontiers in immunology 5, 22. PMID: 24600447
2. Rossjohn, J. et al. (2015) Annual review of immunology 33, 169-200. PMID: 25493333
3. Brownlie, RJ. et al. (2013) Nature reviews. Immunology 13, 257-69. PMID: 23524462
4. Nikolich-Zugich, J. et al. (2004) Nature reviews. Immunology 4, 123-32. PMID: 15040585
Note For research use only.
Isotype Control Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)
Images
  • Anti-Human TRBC2 Recombinant Antibody (SAA1764)

    SDS-PAGE

    SDS-PAGE for Anti-Human TRBC2 Antibody (SAA1764).

Reférences
Fiche technique
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human TRBC2 Recombinant Antibody (SAA1764)

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