Anti-Human TREM2 Recombinant Antibody (SAA0548), FITC (HV166117)

Name: Anti-Human TREM2 Recombinant Antibody (SAA0548), FITC
Brand: abinScience
SKU: HV166117
Price: 223 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

50T
100T

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo	HV166117
Reactividad de especies	Human, Mouse
Aplicaciones	FCM, IF
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG1, kappa
ID de clon	SAA0548
Conjugación	FITC
Objetivo	Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM-2, TREM2
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), FITC
Número de acceso	Q9NZC2
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Triggering receptor expressed on myeloid cells 2 (TREM2) is a ~25 kDa protein. Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia. Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin. 1. Bouchon, A. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 4991-5. PMID: 10799849 2. Yeh, FL. et al. (2016) Neuron 91, 328-40. PMID: 27477018 3. Zhao, Y. et al. (2018) Neuron 97, 1023-1031.e7. PMID: 29518356 4. Sudom, A. et al. (2018) The Journal of biological chemistry 293, 12634-12646. PMID: 29794134 5. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881 6. Filipello, F. et al. (2018) Immunity 48, 979-991.e8. PMID: 29752066 7. Bouchon, A. et al. (2001) The Journal of experimental medicine 194, 1111-22. PMID: 11602640 8. Paloneva, J. et al. (2003) The Journal of experimental medicine 198, 669-75. PMID: 12925681
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.