

| Numéro de catalogue | HV590024 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human TREX1 Polyclonal Antibody (HV590024) is a rabbit polyclonal antibody detecting TREX1. Suitable for Human.
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human TREX1 (Met11-His222). | ||||||||
| Cible | 3'-5' exonuclease TREX1, DNase III, Deoxyribonuclease III, EC:3.1.11.2, TREX1, Three-prime repair exonuclease 1 | ||||||||
| Niveau d'endotoxines | Please contact with the lab for this information. | ||||||||
| Pureté | >95% as determined by SDS-PAGE. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q9NSU2 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Contexte | Three-prime repair exonuclease 1 (TREX1) is a ~33 kDa protein. Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation. Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation. 1. Mazur, DJ. et al. (1999) The Journal of biological chemistry 274, 19655-60. PMID: 10391904 2. Höss, M. et al. (1999) The EMBO journal 18, 3868-75. PMID: 10393201 3. de Silva, U. et al. (2007) The Journal of biological chemistry 282, 10537-43. PMID: 17293595 4. Mohr, L. et al. (2021) Molecular cell 81, 724-738.e9. PMID: 33476576 | ||||||||
| Note | For research use only |




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