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| カタログ番号 | HT270014 | ||||||||
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| 説明 |
Anti-Human TRIAP1 Polyclonal Antibody (HT270014) is a rabbit polyclonal antibody detecting TRIAP1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRIAP1 (Asn2-Ser76). | ||||||||
| ターゲット | TP53-regulated inhibitor of apoptosis 1, Protein 15E1.1, WF-1, p53-inducible cell-survival factor, p53CSV, TRIAP1, 15E1.1, HSPC132 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43715 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | TP53-regulated inhibitor of apoptosis 1 (TRIAP1) is a ~8 kDa protein. Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. 1. Potting, C. et al. (2013) Cell metabolism 18, 287-95. PMID: 23931759 2. Miliara, X. et al. (2015) EMBO reports 16, 824-35. PMID: 26071602 3. Park, WR. et al. (2005) Cancer research 65, 1197-206. PMID: 15735003 | ||||||||
| 注意事項 | For research use only. |
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