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| カタログ番号 | HP506014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRIM11 (Asn297-Arg456). | ||||||||
| ターゲット | Tripartite motif-containing protein 11, RING-type E3 ubiquitin transferase TRIM11, TRIM11, RING finger protein 92, RNF92, E3 ubiquitin-protein ligase TRIM11, Protein BIA1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q96F44 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase TRIM11 is a ~52 kDa protein. E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. 1. Ishikawa, H. et al. (2006) FEBS letters 580, 4784-92. PMID: 16904669 2. Uchil, PD. et al. (2008) PLoS pathogens 4, e16. PMID: 18248090 3. Liu, T. et al. (2016) Cell reports 16, 1988-2002. PMID: 27498865 | ||||||||
| 注意事項 | For research use only. |
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