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| カタログ番号 | HC308014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRIM14 (Ser254-Pro442). | ||||||||
| ターゲット | KIAA0129, Tripartite motif-containing protein 14, TRIM14 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q14142 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Tripartite motif-containing protein 14 (TRIM14) is a ~49 kDa protein. Plays an essential role in the innate immune defense against viruses and bacteria. Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of viral replication. Also plays a role in the inhibition of ebolavirus infection by enhancing IFN-beta and NF-kappa-B activation after binding to the viral protein NP. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. 1. Tan, G. et al. (2018) Frontiers in immunology 9, 1872. PMID: 30150992 2. Hoffpauir, CT. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 205, 153-167. PMID: 32404352 3. Wang, S. et al. (2016) Scientific reports 6, 32336. PMID: 27578425 4. Kuroda, M. et al. (2023) The Journal of infectious diseases 228, S514-S521. PMID: 37562033 5. Zhou, Z. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E245-54. PMID: 24379373 6. Chen, M. et al. (2016) Molecular cell 64, 105-119. PMID: 27666593 7. Liu, D. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119. PMID: 35145029 | ||||||||
| 注意事項 | For research use only. |
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