中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HP976014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRIM15 (Glu80-Pro275). | ||||||||
| ターゲット | ZNF178, Tripartite motif-containing protein 15, TRIM15, ZNFB7, Zinc finger protein 178, RNF93, RING finger protein 93, Zinc finger protein B7 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9C019 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase TRIM15 is a ~52 kDa protein. E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis. Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2. Also plays a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN. Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS. Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. 1. Uchil, PD. et al. (2013) Journal of virology 87, 257-72. PMID: 23077300 2. Zhang, J. et al. (2021) Journal of molecular histology 52, 839-848. PMID: 34142270 3. Zhu, G. et al. (2021) Nature cell biology 23, 978-991. PMID: 34497368 4. Uchil, PD. et al. (2014) Journal of cell science 127, 3928-42. PMID: 25015296 5. Roy, M. et al. (2022) Cellular signalling 91, 110210. PMID: 34871740 | ||||||||
| 注意事項 | For research use only. |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
