Anti-Human TRIM22 Polyclonal Antibody (HC134014)

Name: Anti-Human TRIM22 Polyclonal Antibody
Brand: abinScience
SKU: HC134014
Price: 168 USD
Availability: InStock

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Prix(USD) : --

Spécification :

50ug
100ug

Nombre :

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HC134014

Description

Anti-Human TRIM22 Polyclonal Antibody (HC134014) is a rabbit polyclonal antibody detecting TRIM22. Suitable for Human.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human TRIM22 (Ser317-Ser498).

Cible

50 kDa-stimulated trans-acting factor, E3 ubiquitin-protein ligase TRIM22, EC:2.3.2.27, RING finger protein 94, RING-type E3 ubiquitin transferase TRIM22, RNF94, STAF50, Staf-50, TRIM22, Tripartite motif-containing protein 22

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

Q8IYM9

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Contexte

E3 ubiquitin-protein ligase TRIM22 is a ~56 kDa protein. Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity. Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV). Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A. Also acts by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation. Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter.

1. Yang, C. et al. (2016) Cellular & molecular immunology 13, 94-102. PMID: 25683609

2. Inoue, A. et al. (2022) Biochimica et biophysica acta. Molecular cell research 1869, 119318. PMID: 35777501

3. Zu, S. et al. (2022) Cell & bioscience 12, 139. PMID: 36042495

4. Turrini, F. et al. (2015) Retrovirology 12, 104. PMID: 26683615

5. Fei, X. et al. (2022) Molecular therapy oncolytics 26, 413-428. PMID: 36159777

Note

For research use only

Images

Western blot

Western blot analysis was performed using anti-TRIM22 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: K562 cell lysate
Lane 3: HL-60 cell lysate
Lane 4: Mouse thymus lysate
Lane 5: Mouse lung lysate

Reférences

Fiche technique

Anti-Human TRIM22 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human TRIM22 Polyclonal Antibody (HC134014)

Aperçu

Images

Reférences

Fiche technique

SDS