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| カタログ番号 | HB027014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TRIM27 Polyclonal Antibody (HB027014) is a rabbit polyclonal antibody detecting TRIM27 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRIM27 (Ser315-Pro513). | ||||||||
| ターゲット | RING finger protein 76, Zinc finger protein RFP, RFP, TRIM27, RNF76, RING-type E3 ubiquitin transferase TRIM27, Tripartite motif-containing protein 27, Ret finger protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P14373 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Zinc finger protein RFP (TRIM27) is a ~58 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination of various substrates and thereby plays a role in diffent processes including proliferation, innate immunity, apoptosis, immune response or autophagy. Ubiquitinates PIK3C2B and inhibits its activity by mediating the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. 1. Zurek, B. et al. (2012) PloS one 7, e41255. PMID: 22829933 2. Zaman, MM. et al. (2013) Molecular and cellular biology 33, 4971-84. PMID: 24144979 3. Cai, J. et al. (2018) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 32, 5238-5249. PMID: 29688809 4. Garcia-Garcia, J. et al. (2023) The FEBS journal 290, 1096-1116. PMID: 36111389 5. Hao, YH. et al. (2013) Cell 152, 1051-64. PMID: 23452853 6. Zheng, Q. et al. (2015) Cell research 25, 1121-36. PMID: 26358190 | ||||||||
| 注意事項 | For research use only. |
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