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| カタログ番号 | HT014014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TRIM38 Polyclonal Antibody (HT014014) is a rabbit polyclonal antibody detecting TRIM38 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRIM38 (Asp282-Asp465). | ||||||||
| ターゲット | E3 ubiquitin-protein ligase TRIM38, 2.3.2.27, RING finger protein 15, Tripartite motif-containing protein 38, Zinc finger protein RoRet, TRIM38, RNF15, RORET | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00635 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | E3 ubiquitin-protein ligase TRIM38 is a ~53 kDa protein. E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus. Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters. 1. Xue, Q. et al. (2012) PloS one 7, e46825. PMID: 23056470 2. Hu, MM. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, 1509-14. PMID: 24434549 | ||||||||
| 注意事項 | For research use only. |
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