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Anti-Human TRIM69 Polyclonal Antibody (HP348014)

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Aperçu
Numéro de catalogueHP348014
Description
Anti-Human TRIM69 Polyclonal Antibody (HP348014) is a rabbit polyclonal antibody detecting TRIM69 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human TRIM69 (Thr331-Gln500).
Cible Tripartite motif-containing protein 69, RFP-like domain-containing protein trimless, RNF36, E3 ubiquitin-protein ligase TRIM69, RING finger protein 36, RING-type E3 ubiquitin transferase TRIM69, TRIM69
Purification Purified by antigen affinity column.
Numéro d'accès Q86WT6
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

E3 ubiquitin-protein ligase TRIM69 is a ~57 kDa protein. E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination.

1. Han, Y. et al. (2012) Biochemical and biophysical research communications 429, 6-11. PMID: 23131556
2. Wang, K. et al. (2018) PLoS pathogens 14, e1007287. PMID: 30142214
3. Rihn, SJ. et al. (2019) Journal of virology 93. PMID: 31375575
4. Kueck, T. et al. (2019) Journal of virology 93. PMID: 31578292
5. Rong, X. et al. (2019) Redox biology 22, 101157. PMID: 30844644
6. Song, Y. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2211467119. PMID: 36251989
7. Wang, Y. et al. (2023) Nucleic acids research 51, 10568-10589. PMID: 37739411
Note For research use only.
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Reférences
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human TRIM69 Polyclonal Antibody

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