

| Каталожный номер | HP348014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human TRIM69 Polyclonal Antibody (HP348014) is a rabbit polyclonal antibody detecting TRIM69 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human TRIM69 (Thr331-Gln500). | ||||||||
| Цель | Tripartite motif-containing protein 69, RFP-like domain-containing protein trimless, RNF36, E3 ubiquitin-protein ligase TRIM69, RING finger protein 36, RING-type E3 ubiquitin transferase TRIM69, TRIM69 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q86WT6 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | E3 ubiquitin-protein ligase TRIM69 is a ~57 kDa protein. E3 ubiquitin ligase that plays an important role in antiviral immunity by restricting different viral infections including dengue virus or vesicular stomatitis indiana virus. Ubiquitinates viral proteins such as dengue virus NS3 thereby limiting infection. In addition, acts as a key mediator of type I interferon induced microtubule stabilization by directly associating to microtubules independently of its E3 ligase activity. Also plays a role in cataract formation together with TP53. Mechanistically, inhibits UVB-induced cell apoptosis and reactive oxygen species (ROS) production by inducing TP53 ubiquitination. 1. Han, Y. et al. (2012) Biochemical and biophysical research communications 429, 6-11. PMID: 23131556 2. Wang, K. et al. (2018) PLoS pathogens 14, e1007287. PMID: 30142214 3. Rihn, SJ. et al. (2019) Journal of virology 93. PMID: 31375575 4. Kueck, T. et al. (2019) Journal of virology 93. PMID: 31578292 5. Rong, X. et al. (2019) Redox biology 22, 101157. PMID: 30844644 6. Song, Y. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2211467119. PMID: 36251989 7. Wang, Y. et al. (2023) Nucleic acids research 51, 10568-10589. PMID: 37739411 | ||||||||
| Примечание | For research use only. |
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