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| カタログ番号 | HF906013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1532 | ||||
| ターゲット | TRIO, Triple functional domain protein, PTPRF-interacting protein | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O75962 | ||||
| RRID | Anti-Human TRIO Antibody (SAA1532) (abinScience Cat# HF906013, RRID:AB_3727293) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Triple functional domain protein (TRIO) is a ~346 kDa protein. Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth. Plays a key role in the regulation of neurite outgrowth and lamellipodia formation. In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses. 1. Deinhardt, K. et al. (2011) Science signaling 4, ra82. PMID: 22155786 2. Pengelly, RJ. et al. (2016) Journal of medical genetics 53, 735-742. PMID: 27418539 3. Debant, A. et al. (1996) Proceedings of the National Academy of Sciences of the United States of America 93, 5466-71. PMID: 8643598 4. Seipel, K. et al. (1999) Journal of cell science 112 ( Pt 12), 1825-34. PMID: 10341202 5. Barbosa, S. et al. (2020) American journal of human genetics 106, 338-355. PMID: 32109419 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human TRIO Antibody (SAA1532)
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