

| Каталожный номер | HP705014 | ||||||||
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| Описание |
Anti-Human TRPC4AP Polyclonal Antibody (HP705014) is a rabbit polyclonal antibody detecting TRPC4AP in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| Реактивность видов | Human, Mouse | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human TRPC4AP (Leu427-Lys511). | ||||||||
| Цель | Trp4-associated protein, Protein TRUSS, C20orf188, Protein TAP1, Short transient receptor potential channel 4-associated protein, TRRP4AP, TRPC4AP, Trpc4-associated protein, TNF-receptor ubiquitous scaffolding/signaling protein | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q8TEL6 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Short transient receptor potential channel 4-associated protein (TRPC4AP) is a ~90 kDa protein. Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. 1. Choi, SH. et al. (2010) Genes & development 24, 1236-41. PMID: 20551172 2. Koren, I. et al. (2018) Cell 173, 1622-1635.e14. PMID: 29779948 | ||||||||
| Примечание | For research use only. |
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