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| カタログ番号 | HP583014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human TRPV6/ECaC2 Polyclonal Antibody (HP583014) is a rabbit polyclonal antibody detecting TRPV6/ECaC2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TRPV6/ECaC2 (Ser87-Asp319). | ||||||||
| ターゲット | CaT1, Transient receptor potential cation channel subfamily V member 6, CaT-like, TrpV6, CaT-L, ECAC2, TRPV6, ECaC2, Epithelial calcium channel 2, Calcium transport protein 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9H1D0 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Transient receptor potential cation channel subfamily V member 6 (TRPV6/ECaC2) is a ~87 kDa protein. Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. 1. Peng, JB. et al. (2000) Biochemical and biophysical research communications 278, 326-32. PMID: 11097838 2. Niemeyer, BA. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 3600-5. PMID: 11248124 3. Wissenbach, U. et al. (2001) The Journal of biological chemistry 276, 19461-8. PMID: 11278579 4. Bödding, M. et al. (2004) The Journal of biological chemistry 279, 36546-52. PMID: 15184369 5. Fecher-Trost, C. et al. (2013) The Journal of biological chemistry 288, 16629-16644. PMID: 23612980 6. McGoldrick, LL. et al. (2018) Nature 553, 233-237. PMID: 29258289 | ||||||||
| 注意事項 | For research use only. |
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