

| Каталожный номер | HP583014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human TRPV6/ECaC2 Polyclonal Antibody (HP583014) is a rabbit polyclonal antibody detecting TRPV6/ECaC2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human TRPV6/ECaC2 (Ser87-Asp319). | ||||||||
| Цель | CaT1, Transient receptor potential cation channel subfamily V member 6, CaT-like, TrpV6, CaT-L, ECAC2, TRPV6, ECaC2, Epithelial calcium channel 2, Calcium transport protein 1 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q9H1D0 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Transient receptor potential cation channel subfamily V member 6 (TRPV6/ECaC2) is a ~87 kDa protein. Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. 1. Peng, JB. et al. (2000) Biochemical and biophysical research communications 278, 326-32. PMID: 11097838 2. Niemeyer, BA. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 3600-5. PMID: 11248124 3. Wissenbach, U. et al. (2001) The Journal of biological chemistry 276, 19461-8. PMID: 11278579 4. Bödding, M. et al. (2004) The Journal of biological chemistry 279, 36546-52. PMID: 15184369 5. Fecher-Trost, C. et al. (2013) The Journal of biological chemistry 288, 16629-16644. PMID: 23612980 6. McGoldrick, LL. et al. (2018) Nature 553, 233-237. PMID: 29258289 | ||||||||
| Примечание | For research use only. |
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