Anti-Human TSHR Recombinant Antibody (M22), PerCP (HB852147)

Name: Anti-Human TSHR Recombinant Antibody (M22), PerCP
Brand: abinScience
SKU: HB852147
Price: 268 USD
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Número de catálogo	HB852147
Reactividad de especies	Human
Aplicaciones	FCM
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1
ID de clon	M22
Conjugación	PerCP
Objetivo	Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3
Nivel de endotoxinas	Please contact with the lab for this information.
Productos asociados	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PerCP
Número de acceso	P16473
Forma	Liquid
Buffer de almacenamiento	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Store at 4°C for 12 months. Protect from light. Do not freeze.
Fondo	Thyrotropin receptor (TSHR/LGR3) is a ~86 kDa protein. Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS). 1. Costagliola, S. et al. (2002) The EMBO journal 21, 504-13. PMID: 11847099 2. Nakabayashi, K. et al. (2002) The Journal of clinical investigation 109, 1445-52. PMID: 12045258 3. Faust, B. et al. (2022) Nature 609, 846-853. PMID: 35940205 4. Duan, J. et al. (2022) Nature 609, 854-859. PMID: 35940204 5. Morgan, SJ. et al. (2016) Thyroid : official journal of the American Thyroid Association 26, 1794-1803. PMID: 27638195
Nota	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.