Anti-Human TUFM Polyclonal Antibody (HW446014)

Name: Anti-Human TUFM Polyclonal Antibody
Brand: abinScience
SKU: HW446014
Price: 96 USD
Availability: InStock

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Aperçu
Images
Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HW446014

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human TUFM (Asp67-Gly452).

Cible

P43, Elongation factor Tu, mitochondrial, TUFM, EF-Tu

Purification

Purified by antigen affinity column.

Numéro d'accès

P49411

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Elongation factor Tu, mitochondrial (TUFM) is a ~49 kDa protein. GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.

1. Lei, Y. et al. (2012) Immunity 36, 933-46. PMID: 22749352

2. Ding, B. et al. (2017) Cell host & microbe 21, 538-547.e4. PMID: 28407488

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-TUFM polyclonal antibody at 1μg/ml on various samples.
Lane 1: HepG2 cell lysate
Lane 2: K562 cell lysate
Lane 3: Mouse brain lysate
Lane 4: Mouse kidney lysate
Lane 5: Mouse liver lysate
Lane 6: Rat brain lysate
Lane 7: Rat kidney lysate
Lane 8: Rat liver lysate