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| カタログ番号 | HW446014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human TUFM (Asp67-Gly452). | ||||||||
| ターゲット | P43, Elongation factor Tu, mitochondrial, TUFM, EF-Tu | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P49411 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Elongation factor Tu, mitochondrial (TUFM) is a ~49 kDa protein. GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Participates in mitochondrial translation. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. 1. Lei, Y. et al. (2012) Immunity 36, 933-46. PMID: 22749352 2. Ding, B. et al. (2017) Cell host & microbe 21, 538-547.e4. PMID: 28407488 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-TUFM polyclonal antibody at 1μg/ml on various samples.
Lane 1: HepG2 cell lysate
Lane 2: K562 cell lysate
Lane 3: Mouse brain lysate
Lane 4: Mouse kidney lysate
Lane 5: Mouse liver lysate
Lane 6: Rat brain lysate
Lane 7: Rat kidney lysate
Lane 8: Rat liver lysate
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