

| Numéro de catalogue | HX857014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reactivité des espèces | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human UBE2K (Met1-Asn200). | ||||||||
| Cible | Ubiquitin-conjugating enzyme E2(25K), Ubiquitin-protein ligase, UBE2K, HIP-2, E2 ubiquitin-conjugating enzyme K, Huntingtin-interacting protein 2, Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-conjugating enzyme E2 K, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-25 kDa, HIP2, LIG | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P61086 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Ubiquitin-conjugating enzyme E2 K (UBE2K) is a ~22 kDa protein. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. | ||||||||
| Note | For research use only. |
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